Selective activation of PPAR{gamma} in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance

Selective activation of PPAR{gamma} in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance: "URL: Selective activation of PPAR{gamma} in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance

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Scientists link fat hormone to death from potentially deadly blood infection

Scientists link fat hormone to death from potentially deadly blood infection




A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsis—an overwhelming infection of the blood which claims thousands of lives each year.

Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients.

Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients.

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Surgeons Discover a Visceral Fat Hormone That Could Protect Against Life-threatening Sepsis

"A study exhibited at the conference showed that low levels of the hormone adiponectin placed animals at a profoundly high risk of death from a septic insult." Click here to read more.....

Adipose tissue may play role in COPD-related systemic inflammation

Adipose tissue may play role in COPD-related systemic inflammation

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Smoking cessation significantly increases adiponectin levels

Smoking cessation significantly increases adiponectin levels

Endoplasmic Reticulum Stress

PBDE (flame retardents), dioxins, PCBs etc bioaccumulate in fat tissue. One study shows that agents that cause ER stress result in failure of preadipocyte differentiation, failure to accumulate lipid, inhibit PPAR-gamma and adiponectin and resulted in sustained synthesis of MCP-1. (MCP-1 is associated with sickness syndrome.) Other agents that inhibited GATA during the study seemed to do the same. Suggesting that agents that cause ER stress may inhibit GATA and cause these changes. Adiponecting and PPAR-gamma are both anti-inflammatory regulators.

Shimada, T., Hiramatsu, N., Okamura, M., Hayakawa, K., Kasai, A., Yao, J., and Kitamura, M. (2007). Unexpected blockade of adipocyte differentiation by k-7174: Implication for endoplasmic reticulum stress. Biochemical and Biophysical Research Communications, 363(2):355-360. http://www.citeulike.org/user/HEIRS/article/5436816