During exercise skeletal muscle produces Il-6 which tends to inhibit the production of Tnf-a and Il-1b which are two factors that contribute to the development of sickness syndrome.
Wood, L. J., Nail, L. M., and Winters, K. A. (2009). Does muscle-derived interleukin-6 mediate some of the beneficial effects of exercise on cancer treatment-related fatigue? Oncology nursing forum, 36(5):519-524. http://www.citeulike.org/user/HEIRS/article/5727478
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