TRPV1 and Endoplasmic Reticulum Stress

Activation of TRPV1 can cause endoplasmic reticulum stress which follows a pathway that leads to Nrf2 and unfolded protein response. Diabetes can lead to the unfolded protein response. In addition, chronic diabetic neuropathy can lead to nerve degeneration. DRG from diabetic rats show increased oxidative stress and cell injury. TRPV1 may be an early characteristic of diabetic sensory neuropathy.

• Note: Vitamin D has some preventative characteristics on endoplasmic reticulum stress.
  

Hong, S., Agresta, L., Guo, C., and Wiley, J. W. (2008). The trpv1 receptor is associated with preferential stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy. Journal of Neurochemistry, 105(4):1212-1222.http://www.citeulike.org/user/HEIRS/article/2733060Civelek, M., Manduchi, E., Riley, R. J., Stoeckert, C. J., and Davies, P. F. (2009). Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis. Circ Res, pages CIRCRESAHA.109.203711+. http://www.citeulike.org/user/HEIRS/article/5432618