PGC-1a is an important component for the detoxification of nitrosamines. Excess levels can lead to enhanced toxicity. A recent study shows nitrosamine increases oxidative and nitrosative stress and elevates inflammatory mediators including Tnf-a , MCP-1 and Il-1 by activation of microglia and astrocytes resulting in neuronal damage. Nitrosamines are chemical compounds which are produced from nitrites and secondary amines. Some are carcinogenic are can be produced from certain methods of cooking and are also in beer and latex. (Wipedia)
Ghosh, D., Mishra, M. K. K., Das, S., Kaushik, D. K. K., and Basu, A. (2009). Tobacco carcinogen induces microglial activation and subsequent neuronal damage. Journal of neurochemistry, 110(3):1070-1081. http://www.citeulike.org/user/HEIRS/article/5202108
Nitrosamines. Wipedia. Retrieved on September 6, 2009.
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