Molecular switch Nrf2 prevents cell damage caused by UVB rays from sunlight

Molecular switch prevents cell damage caused by UVB rays from sunlight

ScienceDaily (2010-06-15) -- The protein Nrf2 plays a crucial role in tissue repair and in the protection against carcinogenesis. Cell biologists have now discovered a previously unknown role for this molecular switch, which activates numerous genes that protect cells from stress: it prevents cell damage in the skin caused by UVB rays from the sunlight. In addition, they unraveled the underlying mechanisms of action. ... > read full article

Green Tea Protects Skin From UVB Radiation!

Definition: Dendritic cells (DC) are immune cells that take antigen and present it to other immune cells. They are present in tissue that have direct access to the external environment including the skin, nose, stomach, lungs and intestines. They possess cell-to-cell type interaction which includes communication with cytokines. Wipedia describes one example of their action includes when microbes stimulate antigens to produce IL-12 which primes the immune system for attack on antigens that DCs present. (Wipedia)

Background: Epigallcatechin gallate (EGCG) is a substance found in high amounts in green tea. It has recently been shown in studies to have benefit on the symptoms related to a mouse model of chronic fatigue. (Sachdeva)

Title: Protective effect of epigallocatechin gallate on the immune function of dendritic cells after ultraviolet b irradiation.

Summary: EGCG counteracts the inhibitory effect of UVB radiation on the immune properties of dendritic cells. It was shown in this study to down-regulate the secretion of IL-12 and up-regulates Il-10. The former Il-12 can stimulate the production of Tnf-a and IFN-gamma and is associated with autoimmune disease. The latter has an important role in modulating sickness syndrome.

Citations:

Jin, S. L., Zhou, B. R., and Luo, D. (2009). Protective effect of epigallocatechin gallate on the immune function of dendritic cells after ultraviolet b irradiation. Journal of Cosmetic Dermatology, 8(3):174-180. http://www.citeulike.org/user/HEIRS/article/5700567

Sachdeva, A. K. K., Kuhad, A., Tiwari, V., and Chopra, K. (2009). Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: Behavioral and biochemical evidence. Behavioural brain research. http://www.citeulike.org/user/HEIRS/article/5323625

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