These results show that DFMO potentiates LPS-induced nitrite production in the murine macrophage cell line J774. Since the only known mechanism of action of DFMO is inhibition of ODC, and thus polyamine biosynthesis, we conclude that expression of iNOS can be critically regulated by endogenous polyamines.
CiteULike: Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells.: "Baydoun, A. R. and Morgan, D. M. (1998). Inhibition of ornithine decarboxylase potentiates nitric oxide production in lps-activated j774 cells. British journal of pharmacology, 125(7):1511-1516."
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