I find this interesting ................................... As we have already established there is potential for the Nrf2 to protect astrocytes from damage. Excitotoxicity from glutamate has been implicated in a number of neurodegenerative conditions. As a new report suggests, sulphoraphane and riluzole,a ALS drug, may be more effective combined that each alone to minimize excitotoxicity. The former has been shown to act through Nrf2 while the latter is is presumed at least to improve transport by regulating glutamate transporters. The former I get but as to the latter I do not have a lot of information here....Is caveolin responsible for urea and ammonia leakiness? Do conditions that elevate ammonia...alter proteins that coregulate that influence muscle weakness? Can this be a factor in weakness associated with old age or other illness where excitoxity becomes a factor.? Is this drug, only used for ALS? Just askin? Understanding animal behavior sometimes is alot easier...and wonder why is it that this stuff fascinates me.....? Even if it hard to understand when I do not have a lot to go on.....! Too much to learn, so little time and too little time before I will forget...or not!
Geng Chang, Yansu Guo, Yaqiong Jia, Weisong Duan, Bin Li, Jixu Yu and Chunyan Li, “Protective Effect of Combination of Sulforaphane and Riluzole on Glutamate-Mediated Excitotoxicity”, Biol. Pharm. Bull., Vol. 33, 1477-1483 (2010) . http://www.ncbi.nlm.nih.gov/pubmed/20823560
Mark J Hernandez, Tina M Roberts and Christopher D Hardin. Caveolin-1 and the Organization of Glycolysis in Astrocytes: Modulation by Ammonia. FASEB Journal 2007. 21:748.9 http://www.fasebj.org/cgi/content/meeting_abstract/21/6/A872-c
No comments:
Post a Comment