Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells.

Summary: Control and Nrf2-small interfering RNA-transfected human endothelial cells were treated with vehicle, oleic acid, or OA-NO, and differential gene expression profiles were determined. Although OA-NO significantly induced the expression of Nrf2-dependent genes, including heme oxygenase-1 and glutamate-cysteine ligase modifier subunit, the majority of OA-NO-regulated genes were regulated by Nrf2-independent pathways.....

Kansanen, E., Jyrkkänen, H.-K., Volger, O. L., Leinonen, H., Kivelä, A. M., Häkkinen, S.-K., Woodcock, S. R., Schopfer, F. J., Horrevoets, A. J., Ylä-Herttuala, S., Freeman, B. A., and Levonen, A.-L. (2009). Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells. Journal of Biological Chemistry, 284(48):33233-33241. http://www.citeulike.org/user/HEIRS/article/6189069