Deletion of Nuclear Factor-E2-Related Factor-2 Leads to Rapid Onset and Progression of Nutritional Steatohepatitis in Mice.

Summary: Correlating well with the liver pathology, the mRNA levels of factors involved in fatty acid metabolism, inflammatory cytokines, and fibrogenesis-related genes were significantly increased in the livers of the Nrf-null mice. These findings demonstrate that Nrf2 deletion in mice leads to rapid onset and progression of nutritional steatohepatitis induced by an MCD diet.


Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., and Yamamoto, M. (2009). Deletion of nuclear factor-e2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. American journal of physiology. Gastrointestinal and liver physiology. http://www.citeulike.org/user/HEIRS/article/6189023