Sulforaphane suppresses lps-induced inflammation in primary rat microglia.

Notes: We showed that SF attenuates the LPS-induced increase of IL-1β, IL-6, and TNF-α expression in microglia. In addition, SF significantly decreases the NO in a concentration-dependent manner. SF inhibits LPS-stimulated ERK1/2 and JNK phosphorylation and thereby inhibits the LPS-induced activation of NF-κB- and activator protein-1 (AP-1). Moreover, SF and LPS together are able to induce Nrf2 activation.

Brandenburg, L.-O., Kipp, M., Lucius, R., Pufe, T., and Wruck, C. Sulforaphane suppresses lps-induced inflammation in primary rat microglia. Inflammation Research. http://www.citeulike.org/user/HEIRS/article/6195482