Background: Past studies have demonstrated that D3T a potent enzyme inducer has a positive effect on upregulating the Nrf2 antioxidant system. (Kwak)
Title: Cruciferous nutraceutical 3h-1,2-dithiole-3-thione protects human primary astrocytes against neurocytotoxicity elicited by mptp, mpp(+), 6-ohda, hne and acrolein.
Summary: This is one of the first studies that in "human astrocytes cruciferous nutraceutical D3T potently induces the cellular GSH system and the phase 2 enzyme NQO1, which is accompanied by dramatically increased resistance of these cells to the damage induced by various neurotoxicants. The results of this study may have important implications for the development of novel neuroprotective strategies.
Citation: Jia, Z., Zhu, H., Li, Y., and Misra, H. P. (2009). Cruciferous nutraceutical 3h-1,2-dithiole-3-thione protects human primary astrocytes against neurocytotoxicity elicited by mptp, mpp(+), 6-ohda, hne and acrolein. Neurochemical research, 34(11):1924-1934. http://www.citeulike.org/user/HEIRS/article/4483340
Other References: Kwak, M.-K., Itoh, K., Yamamoto, M., and Kensler, T. W. (2002). Enhanced expression of the transcription factor nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell. Biol., 22(9):2883-2892. http://www.citeulike.org/user/HEIRS/article/883878
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