Conditional knockout of mnsod targeted to type iib skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capac

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Title: Conditional knockout of mnsod targeted to type iib skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.

Summary: "MSOD was reduced while mitochondrial superoxide was increased....this data suggests that elevated mitochondrial oxidative stress and damage in glycolytic muscle fibers is sufficient to reduce contractile muscle function and aerobic exercise capacity."

Lustgarten, M., Jang, Y., Liu, Y., Muller, F., Qi, W., Steinhelper, M., Brooks, S., Larkin, L. M., Shimizu, T., Shirasawa, T., McManus, L., Bhattacharya, A., Richardson, A., and Van Remmen, H. (2009). Conditional knockout of mnsod targeted to type iib skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. American journal of physiology. Cell physiology