Endotoxemia Causes A Decrease in eNOS-Dependant Vasodilation in Microvasculature~!

"experimental endotoxemia in humans causes a specific decrease in endothelial NO-dependent vasodilation in the microcirculation which cannot be explained by a change of ADMA levels. Microvascular NO deficiency might be responsible for the heterogeneity of tissue perfusion observed in sepsis and could be a therapeutic target" Link: ACUTE ENDOTOXEMIA INHIBITS MICROVASCULAR NITRIC OX... [Shock. 2010] - PubMed result:

SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.

"critical role for SphK1 in endotoxin signaling and sepsis-induced inflammatory responses and suggest that inhibition of SphK1 is a potential therapy for septic shock."

CiteULike: SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.:

Recent Links Added to the HEIRS Library!

1. The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1. http://www.citeulike.org/user/HEIRS/article/6430465#
2.Weight loss, body fat mass, and leptin in Parkinson's disease. http://www.citeulike.org/user/HEIRS/article/6429319
3. High-fat diet induces apoptosis of hypothalamic neurons. http://www.citeulike.org/user/HEIRS/article/4292700
4. Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. http://www.citeulike.org/user/HEIRS/article/6429237
5. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). http://www.citeulike.org/user/HEIRS/article/2997140
6. Sympathetic premotor neurons mediating thermoregulatory functions http://www.citeulike.org/user/HEIRS/article/6429118
7. Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats http://www.citeulike.org/user/HEIRS/article/6428977
8. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors http://www.citeulike.org/user/HEIRS/article/6428976
9. Acute and subacute chemical pneumonitis http://www.citeulike.org/user/HEIRS/article/6428868
10. Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner http://www.citeulike.org/user/HEIRS/article/6428693
11. Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3β) on the risk of Parkinson's disease http://www.citeulike.org/user/HEIRS/article/6426071
12. Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo http://www.citeulike.org/user/HEIRS/article/6425259
13. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells http://www.citeulike.org/user/HEIRS/article/1496816
14. Cigarette Smoking Blocks the Protective Expression of Nrf2/ARE Pathway in Peripheral Mononuclear Cells of Young Heavy Smokers Favouring Inflammation http://www.citeulike.org/user/HEIRS/article/6425199
15. Coenzyme Q10 deficiency in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardi. http://www.citeulike.org/user/HEIRS/article/6414392
16. TLR4 is Necessary for Hyaluronan-mediated Airway Hyperresponsiveness After Ozone Inhalation http://www.citeulike.org/user/HEIRS/article/6424875

Nrf2 as a Therapeutic Target for Stroke and Neurodegeneration

Septic shock: Nitric oxide beneficial after all

Septic shock: Nitric oxide beneficial after all: "URL: Septic shock: Nitric oxide beneficial after all

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Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia.

Summary: However, by acting directly in the hypothalamus, TNFalpha can activate thermogenesis and modulate food intake. Here we show that high concentration TNFalpha in the hypothalamus leads to increased O2 consumption/CO2 production, increased body temperature, and reduced caloric intake, resulting in loss of body mass....In addition, the systemic inhibition of beta3-adrenergic signaling results in a reduced body mass loss and increased survival in septic rats. These data suggest hypothalamic TNFalpha action to be important mediator of the wastage syndrome in cachexia.




Arruda, A. P. P., Milanski, M., Romanatto, T., Solon, C., Coope, A., Alberici, L. C., Festuccia, W. T., Hirabara, S. M., Ropelle, E., Curi, R., Carvalheira, J. B., Vercesi, A. E., and Velloso, L. A. (2009). Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology. http://www.citeulike.org/user/HEIRS/article/6368716?updated=1260645988

Sepsis kills more than heart attacks: study

Sepsis kills more than heart attacks: study: "URL: Sepsis kills more than heart attacks: study

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New therapy may be effective against bacterial infections and sepsis

New therapy may be effective against bacterial infections and sepsis

ScienceDaily (2009-11-29) -- A new study found that certain immune cells primarily associated with asthma and allergies may enhance innate immunity and improve clearance of bacterial infections and may be an effective new therapy against bacterial infections and sepsis in humans. ... > read full article

A common ucp2 polymorphism predisposes to stress hyperglycaemia in severe sepsis.

Summary: "A common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis."

Pyle, A., Ibbett, I. M., Gordon, C., Keers, S. M., Walker, M., Chinnery, P. F., and Baudouin, S. V. (2009). A common ucp2 polymorphism predisposes to stress hyperglycaemia in severe sepsis. J Med Genet, 46(11):773-775. http://www.citeulike.org/user/HEIRS/article/6056691

Scientists link fat hormone to death from potentially deadly blood infection

Scientists link fat hormone to death from potentially deadly blood infection




A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsis—an overwhelming infection of the blood which claims thousands of lives each year.

Hypersensitivity of ahr-deficient mice to lps-induced septic shock

Background: Recent studies suggest endotoxin may be a pathway to chronic fatigue syndrome and the associated inflammtory processes associated with it may contribute to a number of other acute, chronic and environmental diseases as well.

Title: Hypersensitivity of ahr-deficient mice to lps-induced septic shock.

Summary: This study suggests that absence of AhR expression results in increased expression of Il-1b and are hypersensitive to shock after exposure to LPS endotoxin.


Citation: Sekine, H., Mimura, J., Oshima, M., Okawa, H., Kanno, J., Igarashi, K., Gonzalez, F. J., Ikuta, T., Kawajiri, K., and Fujii-Kuriyama, Y. (2009). Hypersensitivity of ahr-deficient mice to lps-induced septic shock. Molecular and cellular biology. http://www.citeulike.org/user/HEIRS/article/5971045

Surgeons Discover a Visceral Fat Hormone That Could Protect Against Life-threatening Sepsis

"A study exhibited at the conference showed that low levels of the hormone adiponectin placed animals at a profoundly high risk of death from a septic insult." Click here to read more.....