Nrf2 and DJ1 are consistently upregulated in inflammation in MS

Nrf2 and DJ1 are consistently upregulated in infla... [Free Radic Biol Med. 2010] - PubMed result: "our findings suggest that persistent Nrf2-mediated transcription occurs in active MS lesions, but that this endogenous response is insufficient to prevent ROS-induced cellular damage, which is abundant in inflammatory MS lesions."

Keap1-Nrf2 activation in the presence and absence of DJ-1

Keap1-Nrf2 activation in the presence and absence of DJ-1. Li Gan. 2010; European Journal of Neuroscience - Wiley InterScience: "In addition, overexpression of Nrf2 with adenovirus preferentially in astrocytes from DJ-1-KO mice enhanced survival of neurons under oxidative insults. These findings indicate that activation of the Nrf2–ARE pathway is independent of DJ-1, and Nrf2 activation is a potential therapeutic target to prevent neurodegeneration in sporadic and DJ-1 familial Parkinson's disease."