Folic Acid Mitigated Cardiac Dysfunction by Normal... [Am J Physiol Heart Circ Physiol. 2010] - PubMed result: "folic acid administered post-MI significantly improved cardiac ejection fraction and induced TIMP, CBS, CSE, and 5-MTHFR. We showed that folic acid supplementation resulted in significant improvement of myocardial function after MI. The study eluted the importance of homocysteine metabolism and folic acid supplementation for cardiovascular health in humans."
Further reading: The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1).
Showing posts with label CBS. Show all posts
Showing posts with label CBS. Show all posts
Friday, September 3, 2010
Tuesday, August 17, 2010
New Findings Involving Enxymes that Promote Protective Effects of Hydrogen Sulfide.
Background: It has been suggested that individuals with chemical sensitivity are more susceptible to the effects of hydrogen sulfide even though hydrogen sulfide has beneficial effects at low endogenous or exogenous levels. It has been shown that some of the benefits of H2S are regulated through Nrf2 and HO-1. In Nrf2 knock-outs, H2S fails to elicit the strong antioxidant HO-1 and reduces tissue resistance to oxidative stress.
H2S protects tissue and " is an endogenously produced gaseous signaling molecule with a diverse physiological profile. Its production in mammalian systems has been attributed to 2 key enzymes in the cysteine biosynthesis pathway, cystathionine β-synthase (CBS) and cystathionine -lyase (CGL). A new study provides evidence that animals lacking either CBS or CGL may be more suceptible to oxidative stress but have slightly different presentations diagnostically. The latter may require supplementation with cysteine in deficiency. In either case, the inability to synthesize or utilize H2S may contribute to environmental illnesses.
Calvert, J. W., Jha, S., Gundewar, S., Elrod, J. W., Ramachandran, A., Pattillo, C. B., Kevil, C. G., and Lefer, D. J. (2009). Hydrogen sulfide mediates cardioprotection through nrf2 signaling. Circ Res, 105(4):365-374. http://www.citeulike.org/user/HEIRS/article/5211207?show_msg=already_posted
Ishii, I., Akahoshi, N., Yamada, H., Nakano, S., Izumi, T., and Suematsu, M. (2010). Cystathionine γ-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. Journal of Biological Chemistry, 285(34):26358-26368. http://www.citeulike.org/user/HEIRS/article/7657999
H2S protects tissue and " is an endogenously produced gaseous signaling molecule with a diverse physiological profile. Its production in mammalian systems has been attributed to 2 key enzymes in the cysteine biosynthesis pathway, cystathionine β-synthase (CBS) and cystathionine -lyase (CGL). A new study provides evidence that animals lacking either CBS or CGL may be more suceptible to oxidative stress but have slightly different presentations diagnostically. The latter may require supplementation with cysteine in deficiency. In either case, the inability to synthesize or utilize H2S may contribute to environmental illnesses.
Calvert, J. W., Jha, S., Gundewar, S., Elrod, J. W., Ramachandran, A., Pattillo, C. B., Kevil, C. G., and Lefer, D. J. (2009). Hydrogen sulfide mediates cardioprotection through nrf2 signaling. Circ Res, 105(4):365-374. http://www.citeulike.org/user/HEIRS/article/5211207?show_msg=already_posted
Ishii, I., Akahoshi, N., Yamada, H., Nakano, S., Izumi, T., and Suematsu, M. (2010). Cystathionine γ-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. Journal of Biological Chemistry, 285(34):26358-26368. http://www.citeulike.org/user/HEIRS/article/7657999
Sunday, September 6, 2009
H2S and Irritable Bowel Syndrome
This just published study has indentified the upregulation of CBS and H2S from colonic bacteria as important signallers in visceral hypersensitivity associated with irritable bowel syndrome in a rat model. CBS plays an important role in the removal of homocysteine and synthesis of cysteine, a precursor of glutathione. DRG CBS-producing neurons are positive for TRPV1 and P2X3R establishing a role of nociception and H2S/CBS signaling of pain even without noticeable evidence of inflammatory processes. CBS neurons are an additional source of H2S in addition to sulfate-producing bacteria in the gastrointestinal tract.
Xu, G. Y., Winston, J., Shenoy, M., Zhou, S., Chen, J., and Pasricha, P. (2009). The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome. Molecular Pain, 5(1):44+. http://www.citeulike.org/user/HEIRS/article/5395457
Cystathionine ß – Synthase (CBS): The Sulfur Amino Acid Metabolism. http://www.uchsc.edu/cbs/cbsdata/cbs_02.htm
Xu, G. Y., Winston, J., Shenoy, M., Zhou, S., Chen, J., and Pasricha, P. (2009). The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome. Molecular Pain, 5(1):44+. http://www.citeulike.org/user/HEIRS/article/5395457
Cystathionine ß – Synthase (CBS): The Sulfur Amino Acid Metabolism. http://www.uchsc.edu/cbs/cbsdata/cbs_02.htm
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