Background: It has been suggested that individuals with chemical sensitivity are more susceptible to the effects of hydrogen sulfide even though hydrogen sulfide has beneficial effects at low endogenous or exogenous levels. It has been shown that some of the benefits of H2S are regulated through Nrf2 and HO-1. In Nrf2 knock-outs, H2S fails to elicit the strong antioxidant HO-1 and reduces tissue resistance to oxidative stress.
H2S protects tissue and " is an endogenously produced gaseous signaling molecule with a diverse physiological profile. Its production in mammalian systems has been attributed to 2 key enzymes in the cysteine biosynthesis pathway, cystathionine β-synthase (CBS) and cystathionine -lyase (CGL). A new study provides evidence that animals lacking either CBS or CGL may be more suceptible to oxidative stress but have slightly different presentations diagnostically. The latter may require supplementation with cysteine in deficiency. In either case, the inability to synthesize or utilize H2S may contribute to environmental illnesses.
Calvert, J. W., Jha, S., Gundewar, S., Elrod, J. W., Ramachandran, A., Pattillo, C. B., Kevil, C. G., and Lefer, D. J. (2009). Hydrogen sulfide mediates cardioprotection through nrf2 signaling. Circ Res, 105(4):365-374. http://www.citeulike.org/user/HEIRS/article/5211207?show_msg=already_posted
Ishii, I., Akahoshi, N., Yamada, H., Nakano, S., Izumi, T., and Suematsu, M. (2010). Cystathionine γ-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. Journal of Biological Chemistry, 285(34):26358-26368. http://www.citeulike.org/user/HEIRS/article/7657999
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