Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion.

This would be an interesting explanation at the hypothesis that the failure to adapt leads to environmental illess. Of course, the failure of the Nrf2 antioxidant system to work effectively is also maladaptive...and there has been studies that suggest that Nrf2 may regulate this pathway to some extent. Lowering protein levels may be an additional way to reduce some EI symptoms and deserves much further study!

". In response to increased NH(4)(+)/NH(3) concentration in the colon, the increased capacity of the colonocytes to synthesize l-ornithine is likely to correspond to an elevated l-ornithine requirement for the elimination of excessive blood ammonia in the liver urea cycle"

Read more: CiteULike: Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion.: