Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster

"Ingestion of the antioxidant, Vitamin E, improved the survival span and delayed the VOC-mediated changes in dopaminergic neurons indicating that the VOC-mediated toxicity was due, in part, to generation of reactive oxygen species"

Link: CiteULike: Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster:

Notes:
*******Another study demonstrates that ochratoxin, a mycotoxin formed from certain molds, inhibit glutathione production and inhibits translocation and activation of Nrf2 (Boesch-Saadatmandi).


















Boesch-Saadatmandi, C., Wagner, A. E., Graeser, A. C., Hundhausen, C., Wolffram, S., and Rimbach, G. (2009). Ochratoxin a impairs nrf2-dependent gene expression in porcine kidney tubulus cells. Journal of animal physiology and animal nutrition, 93(5):547-554. http://www.citeulike.org/user/HEIRS/article/4365611

Inamdar, A. A., Masurekar, P., and Bennett, J. W. (2010). Neurotoxicity of fungal volatile organic compounds in drosophila melanogaster. Toxicol. Sci., pages kfq222+. http://www.citeulike.org/user/HEIRS/article/7529557