Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.

CiteULike: Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.: "results suggest that estrogen-receptor signaling pathway has an inhibitory effect on NRF2-dependent enzymes. Moreover, shikonin, a compound used in ancient chinese medicine reverses the inhibitory effects of estrogen on this pathway and may contribute to breast cancer prevention."