It is hence likely that piceatannol modifies specific cysteine residues of Keap1, which allows Nrf2 to translocate into the nucleus and bind to ARE, leading to enhancement of the expression of HO-1. The characteristic catechol moiety of piceatannol appears to be critical for induction of Nrf2 activation and subsequent upregulation of HO-1.
CiteULike: Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling.: "Lee, H.-H. H., Park, S.-A. A., Almazari, I., Kim, E.-H. H., Na, H.-K. K., and Surh, Y.-J. J. (2010). Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of are-driven nrf2 signaling. Archives of biochemistry and biophysics."
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