High Fat Diet Increases Oxidative Stress and Cognitive Impairment in Mice Brain Through reduced Nrf2

These data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD-induced declines in cognitive performance in the aged brain.

CiteULike: High Fat Diet Increases Hippocampal Oxidative Stress and Cognitive Impairment in Aged Mice: Implications for decreased Nrf2 signaling.: "Morrison, C. D., Pistell, P. J., Ingram, D. K., Johnson, W. D., Liu, Y., Fernandez-Kim, S. O. O., White, C. L., Purpera, M. N., Uranga, R. M., Bruce-Keller, A. J., and Keller, J. N. (2010). High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: Implications for decreased nrf2 signaling. Journal of neurochemistry."