dietary BPA exposure was shown to hypomethylate both the A(vy) and the Cabp(IAP) metastable epialleles. This hypomethylating effect was counteracted with dietary supplementation of methyl donors or genistein. These results are consistent with reports of BPA and other EDCs causing epigenetic effects. Epigenotoxicity could lead to numerous developmental, metabolic, and behavioral disorders in exposed populations. The heritable nature of epigenetic changes also increases the risk for transgenerational inheritance of phenotypes. Thus, epigenotoxicity must be considered when assessing these compounds for safety.
CiteULike: Epigenomic disruption: The effects of early developmental exposures.: "Bernal, A. J. and Jirtle, R. L. (2010). Epigenomic disruption: The effects of early developmental exposures. Birth defects research. Part A, Clinical and molecular teratology."
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