Corticosterone is a main glucocorticoid involved in regulation of fuel, immune reactions, and stress responses. (Corticosterone: Wipedia)"This study suggests that the resistance of the hippocampal BDNF expression to suppression by corticosterone, as seen after water maze training, may contribute to an optimal memory performance." (Schaff)
Comment: It has been suggested that exercise exerts its influence by increasing a number of different hormones and cellular activators including BDNF and enhances memory and learning by activating the antioxidant system. (Ayoub) BDNF has been implicated as a factor in a number of mood disorders and altered levels in conditions including PTSD, fibromyagia and CFS and proteins such as GSK-3b may alter BDNF's downstream regulators. (Mai)
For more: HEIRS Library Tag: BDNF
Related Blogs: BDNF
Recommended:
CiteULike: Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation.: "suggest that the resistance of the hippocampal BDNF expression to suppression by corticosterone, as seen after water maze training, may contribute to an optimal memory performance."
Schaaf, M. J., De Kloet, E. R., and Vreugdenhil, E. (2000). Corticosterone effects on bdnf expression in the hippocampus. implications for memory formation. Stress (Amsterdam, Netherlands), 3(3):201-208. http://www.citeulike.org/user/HEIRS/article/7224956
Other Sources:
Ayoub, R. S. (2009). Effect of exercise on spatial learning and memory in male diabetic rats. 18(3). http://www.citeulike.org/user/HEIRS/article/7224997
Mai, L., Jope, R. S., and Li, X. (2002). Bdnf-mediated signal transduction is modulated by gsk3β and mood stabilizing agents. Journal of Neurochemistry, 82(1):75-83. http://www.citeulike.org/user/HEIRS/article/6621876
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