Green tea polyphenol ECGC reduces endothelin-1 expression and secretion in vascular endothelial cells: Roles for amp-activated protein kinase, akt, and foxo1.

Summary: We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells, in part, via Akt- and AMPK-stimulated FOXO1 regulation of the ET-1 promoter. These findings may be relevant to beneficial cardiovascular actions of green tea.

Reiter, C. E., Kim, J.-A. A., and Quon, M. J. (2009). Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: Roles for amp-activated protein kinase, akt, and foxo1. Endocrinology.