Tuesday, November 24, 2009

Chinese drywall linked to irritation. Is TRPA1 Activation a Factor?

Background: A past study has shown that H2S, cinnaldehyde and isothiocyanates can activate TRPA1 channels in the urinary bladder altering function.  (Gratske) This would suggest that the health effects of Chinese drywall are at least in part, mediated by the effect of both formaldehyde and H2S on TRPA1 channels.


The Consumer Product Safety Commission has some unsettling advice for people who live in homes built with Chinese-made drywall: "Spend as much time outdoors in fresh air as possible. According to the article.........."While hydrogen sulfide and formaldehyde were found at levels lower than the amount considered to be irritants, officials speculated that the two could be combining to produce higher levels of irritation than either would alone......Representatives of the formaldehyde industry said it is irresponsible to speculate that the two substances, at the levels found in the CPSC study, can act in a synergistic manner."

Read complete article.

Related article: Research Reveals Exactly How Coughing Is Triggered By Environmental Irritants

Transient receptor potential A1 (TRPA1) ion channel activity in the human urethra - evidence for a functional role of TRPA1 in the outflow region.
http://www.icsoffice.org/ASPNET_Membership/Membership/Abstracts/Publish/46/000027.pdf

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