Polychlorinated biphenyl (pcb)-induced oxidative stress and cytotoxicity can be mitigated by antioxidants following exposure.

Title: Polychlorinated biphenyl (pcb)-induced oxidative stress and cytotoxicity can be mitigated by antioxidants following exposure.

Summary: "exposure of exponentially growing human breast and prostate epithelial cells to PCBs causes increased steady-state levels of intracellular O(2)(-) and H(2)O(2), induction of MnSOD or CuZnSOD activities, as well as clonogenic cell killing that could be inhibited by a clinically relevant thiol antioxidant, NAC, as well as by catalase and superoxide dismutase following PCB exposure."

Zhu, Y., Kalen, A. L., Li, L., Lehmler, H.-J. J., Robertson, L. W., Goswami, P. C., Spitz, D. R., and Aykin-Burns, N. (2009). Polychlorinated biphenyl (pcb)-induced oxidative stress and cytotoxicity can be mitigated by antioxidants following exposure. Free radical biology & medicine. http://www.citeulike.org/group/7833/article/5872908