Pgc-1β: A regulator of mitochondrial function with subtle roles in energy metabolism

"As expected from PGC-1β’s ability to stimulate mitochondrial function, the loss of PGC-1β decreased the transcription of genes encoding many of the mitochondrial proteins that generate ATP and heat. Yet the mutant mice appeared essentially healthy under normal conditions. Still, a slight impairment of mitochondrial function might lead to some metabolic imbalance, for instance obesity, since mitochondria burn energy that would otherwise be stored as fat."

Chanut, F. (2006). Pgc-1β: A regulator of mitochondrial function with subtle roles in energy metabolism. PLoS Biol, 4(11):e402+. http://www.citeulike.org/user/HEIRS/article/6016816