Nuerotoxicity, Noradrenaline and Il-1

Title:

Summary: "In parallel with its ability to increase IL-1ra and IL-1RII, noradrenaline prevented neurotoxicity in cortical primary neurons induced by conditioned medium from IL-1beta treated mixed glial cells. These data indicate that noradrenaline negatively regulates IL-1 system in glial cells and has neuroprotective properties in situations where IL-1 contributes to pathology."

Citation: McNamee, E. N., Ryan, K. M., Kilroy, D., and Connor, T. J. (2009). Noradrenaline induces il-1ra and il-1 type ii receptor expressions in primary glial cells and protects against il-1beta-induced neurotoxicity. European journal of pharmacology. http://www.citeulike.org/user/HEIRS/article/5923308