Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

Title: Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.

Summary: Saturated and unsaturated fats were studied to determine the effects of glucose metabolism and mitochondrial function. Palmitic acid and stearate decreased mitochondrial function which was determined by hyperpolarization and generation of ATP. They also decreased Akt activation by insulin. Unsaturated fat did not disturb mitochondrial function or glucose metabolism. This study shows that in muscle cells saturated FFA-induced mitochondrial dysfunction associated with impaired insulin-induced glucose metabolism


Citation: Hirabara, S. M., Curi, R., and Maechler, P. (2009). Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. Journal of Cellular Physiology. http://www.citeulike.org/group/6182/article/5843695