Monday, September 21, 2009

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival. Journal of Neural Transmission

......"recent findings on new functions of mitochondria in regulation of their redox state and function through reversible “S-glutathionylation”, a mixed disulfide binding between sulfhydryl groups of GSH and protein cysteine in complex I subunits. Type A monoamine oxidase (MAO-A) localized at the mitochondrial outer membrane is a binding site of neurotoxins leading to apoptosis.

Naoi, M., Maruyama, W., Yi, H., Inaba, K., Akao, Y., and Shamoto-Nagai, M. Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival. Journal of Neural Transmission.http://www.citeulike.org/user/HEIRS/article/5812429

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