Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Title: Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Summary: The author writes, "The production of IL-6 and tumor necrosis factor (TNF)-alpha by LPS was significantly elevated in Ahr-deficient macrophages compared with that in wild-type (WT) cells. Ahr-deficient mice were more highly sensitive to LPS-induced lethal shock than WT mice. Signal transducer and activator of transcription 1 (Stat1) deficiency, as well as Ahr deficiency, augmented LPS-induced IL-6 production. We found that Ahr forms a complex with Stat1 and nuclear factor-kappa B (NF-kappaB) in macrophages stimulated by LPS, which leads to inhibition of the promoter activity of IL-6."


Kimura, A., Naka, T., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii-Kuriyama, Y., and Kishimoto, T. (2009). Aryl hydrocarbon receptor in combination with stat1 regulates lps-induced inflammatory responses. J. Exp. Med., 206(9):2027-2035. http://www.citeulike.org/user/HEIRS/article/5700353