Health and Environmental Illness Research Blog

Tuesday, January 12, 2010

Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene

CiteULike: Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene: "Sparfel, L., Pinel-Marie, M.-L., Boize, M., Koscielny, S., Desmots, S., Pery, A., and Fardel, O. (2010). Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol. Sci., pages kfq007+."

Monday, January 11, 2010

Gene Variants and Pesticide Exposure Increase Risk of Parkinson’s Disease

Beyond Pesticides Daily News Blog » Blog Archive » Gene Variants and Pesticide Exposure Increase Risk of Parkinson’s Disease

Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055 induced lung infection in BALB/c mice.

CiteULike: Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055 induced lung infection in BALB/c mice.: "Bansal, S. and Chhibber, S. (2010). Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during klebsiella pneumoniae b5055 induced lung infection in balb/c mice. Journal of medical microbiology."

Interaction between oxidative stress sensor NRF2 and AhR in the regulation of the phase II detoxification UDP- GST1A10

In the past, we have noted that both the proper function of the AhR and Nrf2 may coordinate detoxification activities. This new study provides evidence that evidence that both are necessary for the induction of enzymes necessary for detoxification of substance including "steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites." KalthoffWipedia As we have noted, EGCG has been demonstrated to have beneficial properties. The chemical EGCG found in green tea has been demonstrated to increase both UGT1A8 and UGT1A10 and has been shown to be dependant on Nrf2 expression. (Yang)

CiteULike: Interaction between oxidative stress sensor nuclear factor erythroid 2-related factor 2 (NRF2) and xenobiotic activated aryl hydrocarbon receptor (AHR) in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10.: "Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P., and Strassburg, C. P. (2010). Interaction between oxidative stress sensor nuclear factor erythroid 2-related factor 2 (nrf2) and xenobiotic activated aryl hydrocarbon receptor (ahr) in the regulation of the human phase ii detoxifying udp-glucuronosyltransferase 1a10. The Journal of biological chemistry."

Yang, X.-y. Y., Zhao, W.-p. P., Li, Y.-q. Q., Sun, Z.-y. Y., Zhang, Y., Guo, Y.-t. T., Yuan, J.-h. H., Zhu, Q., and Wang, M. (2006). [the role of nf-e2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1a and its isoforms by epigallocatechin gallate in colon cancer cells]. Zhonghua yi xue za zhi, 86(2):82-87.
http://www.citeulike.org/user/HEIRS/article/6525255

Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia

This has some important implications for those taking antidepressants as well as, typical behavior of NE in inflammatory responses of the microglia.

CiteULike: Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia: "Schlachetzki, J., Fiebich, B., Haake, E., de Oliveira, A., Jali, E. C., Heneka, M., and Hull, M. (2010). Norepinephrine enhances the lps-induced expression of cox-2 and secretion of pge2 in primary rat microglia. Journal of Neuroinflammation, 7(1):2+."