Interaction between oxidative stress sensor NRF2 and AhR in the regulation of the phase II detoxification UDP- GST1A10

In the past, we have noted that both the proper function of the AhR and Nrf2 may coordinate detoxification activities. This new study provides evidence that evidence that both are necessary for the induction of enzymes necessary for detoxification of substance including "steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites." KalthoffWipedia As we have noted, EGCG has been demonstrated to have beneficial properties. The chemical EGCG found in green tea has been demonstrated to increase both UGT1A8 and UGT1A10 and has been shown to be dependant on Nrf2 expression. (Yang)



CiteULike: Interaction between oxidative stress sensor nuclear factor erythroid 2-related factor 2 (NRF2) and xenobiotic activated aryl hydrocarbon receptor (AHR) in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10.: "Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P., and Strassburg, C. P. (2010). Interaction between oxidative stress sensor nuclear factor erythroid 2-related factor 2 (nrf2) and xenobiotic activated aryl hydrocarbon receptor (ahr) in the regulation of the human phase ii detoxifying udp-glucuronosyltransferase 1a10. The Journal of biological chemistry."

Yang, X.-y. Y., Zhao, W.-p. P., Li, Y.-q. Q., Sun, Z.-y. Y., Zhang, Y., Guo, Y.-t. T., Yuan, J.-h. H., Zhu, Q., and Wang, M. (2006). [the role of nf-e2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1a and its isoforms by epigallocatechin gallate in colon cancer cells]. Zhonghua yi xue za zhi, 86(2):82-87.
http://www.citeulike.org/user/HEIRS/article/6525255