Melatonin Metabolite Levels Associated with Migraine

Title: Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities

Summary: This study suggest a relationship between urinary melatonin and migraine. An inverse correlation of melatonin to anxiety, depression and fatigue that points to a hypothalamic function in migraine.

Citation: Masruha, M. R., Lin, J., de Souza Vieira, D. S., Minett, T. S., Cipolla-Neto, J., Zukerman, E., Vilanova, L. C., and Peres, M. F. (2009). Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. Headache. http://www.citeulike.org/user/HEIRS/article/5947791

Urinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbidities

"This may be the first study to evaluate the relationship between the urinary concentration of melatonin and migraine comorbidities. These results support hypothalamic involvement in migraine pathophysiology."

Urinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbidities