Showing posts with label Q10. Show all posts
Showing posts with label Q10. Show all posts

Wednesday, December 23, 2009

Recent Links Added to the HEIRS Library!

1. The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1. http://www.citeulike.org/user/HEIRS/article/6430465#
2.Weight loss, body fat mass, and leptin in Parkinson's disease. http://www.citeulike.org/user/HEIRS/article/6429319
3. High-fat diet induces apoptosis of hypothalamic neurons. http://www.citeulike.org/user/HEIRS/article/4292700
4. Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. http://www.citeulike.org/user/HEIRS/article/6429237
5. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). http://www.citeulike.org/user/HEIRS/article/2997140
6. Sympathetic premotor neurons mediating thermoregulatory functions http://www.citeulike.org/user/HEIRS/article/6429118
7. Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats http://www.citeulike.org/user/HEIRS/article/6428977
8. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors http://www.citeulike.org/user/HEIRS/article/6428976
9. Acute and subacute chemical pneumonitis http://www.citeulike.org/user/HEIRS/article/6428868
10. Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner http://www.citeulike.org/user/HEIRS/article/6428693
11. Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3β) on the risk of Parkinson's disease http://www.citeulike.org/user/HEIRS/article/6426071
12. Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo http://www.citeulike.org/user/HEIRS/article/6425259
13. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells http://www.citeulike.org/user/HEIRS/article/1496816
14. Cigarette Smoking Blocks the Protective Expression of Nrf2/ARE Pathway in Peripheral Mononuclear Cells of Young Heavy Smokers Favouring Inflammation http://www.citeulike.org/user/HEIRS/article/6425199
15. Coenzyme Q10 deficiency in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardi. http://www.citeulike.org/user/HEIRS/article/6414392
16. TLR4 is Necessary for Hyaluronan-mediated Airway Hyperresponsiveness After Ozone Inhalation http://www.citeulike.org/user/HEIRS/article/6424875

Nrf2 as a Therapeutic Target for Stroke and Neurodegeneration

Sunday, December 20, 2009

CoQ10 deficiency is related to fatigue, autonomic and neurocognitive symptoms in chronic fatigue syndrome.

Summary: The author suggests that patients with ME/CFS would benefit from CoQ10 supplementation in order to normalize the low CoQ10 syndrome. They also propose that earlier mortality from CHF in CFs may be a consequence of coQ10 deficiency. They do note that statins may be contraindicated because they reduce Q10.


Maes, M., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., and Bosmans, E. (2009). Coenzyme q10 deficiency in myalgic encephalomyelitis / chronic fatigue syndrome (me/cfs) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in me/cfs due to cardi. Neuro endocrinology letters, 30(4). http://www.citeulike.org/user/HEIRS/article/6414392

HEIRS Library: Q10

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Monday, October 26, 2009

Inhibition of liver fibrosis by solubilized coenzyme q10: Role of nrf2 activation

Title: Inhibition of liver fibrosis by solubilized coenzyme q10: Role of nrf2 activation in inhibiting transforming growth factor-beta1 expression.


Summary: "CoQ10 inhibited DMN-induced liver fibrosis through suppression of TGF-beta1 expression via Nrf2/ARE activation."

Choi, H.-K. K., Pokharel, Y. R. R., Lim, S. C. C., Han, H.-K. K., Ryu, C. S. S., Kim, S. K. K., Kwak, M. K. K., and Kang, K. W. W. (2009). Inhibition of liver fibrosis by solubilized coenzyme q10: Role of nrf2 activation in inhibiting transforming growth factor-beta1 expression. Toxicology and applied pharmacology, 240(3):377-384. http://www.citeulike.org/user/HEIRS/article/5366863