PON1 Polymorphisms May Alter Risk for Osteoporosis~!

"Mackinnon, E. S., El-Sohemy, A., Rao, A. V., and Rao, L. G. (2010). Paraoxonase 1 polymorphisms 172t→a and 584a→g modify the association between serum concentrations of the antioxidant lycopene and bone turnover markers and oxidative stress parameters in women 25–70 years of age. Journal of Nutritgenetics and Nutrigenomics, 3(1)."

CiteULike: Paraoxonase 1 Polymorphisms 172T→A and 584A→G Modify the Association between Serum Concentrations of the Antioxidant Lycopene and Bone Turnover Markers and Oxidative Stress Parameters in Women 25–70 Years of Age:

Paraoxonase 1 (pon1) expression in hepatocytes is upregulated by pomegranate polyphenols: A role for ppar-gamma pathway

Summary: PJ polyphenols upregulated the hepatocyte PON1 expression, at least in part, via the intracellular signaling cascade PPARgamma-PKA-cAMP.

Citation: Khateeb, J., Gantman, A., Kreitenberg, A. J., Aviram, M., and Fuhrman, B. (2009). Paraoxonase 1 (pon1) expression in hepatocytes is upregulated by pomegranate polyphenols: A role for ppar-gamma pathway. Atherosclerosis. http://www.citeulike.org/user/HEIRS/article/5760999