Downstream mechanisms of nitric oxide-mediated skeletal muscle glucose uptake during contraction.

In oher blogs, I discuss this pathway alot in reference to a number of conditions in environmental illness. In addition, I also mention how specific toxicants may "knock-out" this pathway and therefore provides clues into understanding chemical sensitivity and certain exposures. Unfortunately, it also provides evidence that some therapies that are advocated and out there in the mainstream may be counterproductive depending on the symptoms experienced. Of course, this is up to therapy doctors to determine.

"NOS-derived oxidants regulate skeletal muscle glucose uptake during ex vivo contractions via a cGMP/PKG-, AMPK-, and p38 MAPK-independent pathway. In addition, it appears that NO and ROS may regulate skeletal muscle glucose uptake during contraction through a similar pathway."



Merry, T. L., Lynch, G. S. & McConell, G. K. Downstream mechanisms of nitric oxide-mediated skeletal muscle glucose uptake during contraction. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 299, R1656-R1665 (2010). URL http://dx.doi.org/10.1152/ajpregu.00433.2010.