Alterations in Hepatic mRNA Expression of Phase-II... [Toxicol Sci. 2010] - PubMed result

Alterations in Hepatic mRNA Expression of Phase-II... [Toxicol Sci. 2010] - PubMed result: "HNF4a deficiency markedly alters hepatic mRNA expression of a large number of phase-II enzymes and transporters, probably due to the loss of HNF4a, which is a transactivator and a determinant of gender-specific expression, and/or adaptive activation of signaling pathways important in hepatic regulation of these phase-II enzymes and transporters"