Mycotoxin Downregulates Nrf2 -Causes Brain Oxidative Stress

CiteULike: Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice.: "T-2 toxin exposure resulted in down regulation of transcription factor Nrf2 and its downstream target genes of phase II detoxifying enzymes NQO1, Gclc, Gclm and hemeoxygenase-1. Results of our study show that percutaneously and subcutaneously applied T-2 toxin can cause brain oxidative damage possibly after crossing blood-brain barrier by altering its permeability."