Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis: "summary, we have demonstrated the differential ability of NO and NO-related species to induce apoptosis in human MDMϕ, and have established that ONOO-, but not NO radical, is pro-apoptotic in this cell type (figure ​(figure5).5). Furthermore, our results demonstrate the presence of a cGMP-dependent pre-conditioning mechanism to limit ONOO--induced apoptosis in human macrophages."