Background: FOXO3a is a protein that is an important regulator of oxidative stress by modulating antioxidants like catalase, influences aging, is a tumor repressor, reduced in Nrf2 animals and may contribute to fertility problems. It is found in higher amounts in centenarians, meaning those that live to a hundred years or more. Its activity can be effected by methylation and acetylation. (Wipedia-FOXO3a)
"Borniquel, S., García-Quintáns, N., Valle, I., Olmos, Y., Wild, B., Martínez-Granero, F., Soria, E., Lamas, S., and Monsalve, M. (2010). Inactivation of foxo3a and subsequent downregulation of pgc-1alpha mediate nitric oxide-induced endothelial cell migration. Molecular and cellular biology, 30(16):4035-4044."
CiteULike: Inactivation of Foxo3a and Subsequent Downregulation of PGC-1alpha Mediate Nitric Oxide-Induced Endothelial Cell Migration.:
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