Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: Role for Mitochondria & Nrf2~!

"We hypothesize that diminished Nrf2/ARE activity contributes to increased oxidative stress and mitochondrial dysfunction in the vasculature leading to endothelial dysfunction, insulin resistance, and abnormal angiogenesis observed in diabetes. Sustained hyperglycemia further exacerbates redox dysregulation, thereby providing a positive feedback loop for severe diabetic complications"Mary Ann Liebert, Inc. - Antioxidants & Redox Signaling - 0(0)::