Background: It has been suggested that environmental illnesses such as chemical sensitivity entails a "loss of tolerance". Interestingly, it has also been proposed that the condition also be associated with inflammation in the gut and supports claims that it often develops after infection. Endotoxin activates the protein GSK-3b which has been shown to negatively influence the activities of beta-catenin and also the Nrf2. A new study by Manicassamy et al supports the necessity for beta-catenin in the development of tolerogenic dendritic cells. Another important note is the role of DISC1 which has been implicated in a number of mental disorders and subset of chronic fatigue syndrome inhibits GSK-3b activity. The beta-catenin pathway is also responsible for toxin removal of ammonia.
Activation of {beta}-Catenin in Dendritic Cells Re... [Science. 2010] - PubMed result: "Activation of {beta}-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine."
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