Saturday, July 31, 2010

Mediation of Inflammation by Walnuts via TLR4

"Walnut extract also induced a decrease in tumor necrosis-alpha (TNFalpha) production. We further found that walnut extract induced internalization of the LPS receptor, toll-like receptor 4, and that the anti-inflammatory effects of walnut were dependent on functional activation of phospholipase D2. These studies represent the first to describe the anti-inflammatory effects of walnuts in microglia, which could lead to nutritional interventions in the prevention and treatment of neurodegeneration."


Willis, L. M., Bielinski, D. F., Fisher, D. R., Matthan, N. R., and Joseph, J. A. (2010). Walnut extract inhibits lps-induced activation of bv-2 microglia via internalization of tlr4: Possible involvement of phospholipase d2. Inflammation.
http://www.citeulike.org/user/HEIRS/article/6822152?show_msg=already_posted





HEIRS Health Research Blog: Oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice.

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