Dioxin and Its Effects on Fat Metabolism and Insulin-Mediated Glucose Regulation~!

Hsu, H.-F. F., Tsou, T.-C. C., Chao, H.-R. R., Kuo, Y.-T. T., Tsai, F.-Y. Y., and Yeh, S.-C. C. (2010). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3t3-l1 cells. Journal of hazardous materials.

This study shows in vitro evidence of TCDD's effects on fat cell metabolism, suggesting dioxin exposure in development of insulin resistance and type II diabetes. Interestingly, while PPAR-gamma was reduced an inhibitor of the AhR did not alter the change in glucose uptake.

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