Resistin decreases eNOS and May Play Major Role in Oxidative Stress and Mitochondrial Dysfuntion!

Resistin: Resistin is a protein secreted by immune and epithelial cells in some mammals including primates and dogs and secreted in adipocytes in mice and rats. Recent discoveries of its role include inflammation and energy regulation as well as, observations in playing a part in insulin resistance. (Wipedia)

Three antioxidants, seleno-L-methionine, ginsenoside Rb1, and MnTBAP (superoxide dismutase mimetic), effectively blocked resistin-induced eNOS downregulation....Thus resistin directly induces eNOS downregulation through overproduction of ROS and activation of p38 and JNK in HCAECs. Resistin-induced mitochondrial dysfunction and imbalance in cellular redox enzymes may be the underlying mechanisms of oxidative stress.

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CiteULike: Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells: "Chen, C., Jiang, J., Lu, J.-M., Chai, H., Wang, X., Lin, P. H., and Yao, Q. (2010). Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol, 299(1):H193-201."