Light Therapy Decreases Certain Immune Complexes While Increasing Tregs in psoriasis-like condition~!

PUVA induced the Th2 pathway and IL-10-producing CD4+CD25+Foxp3+Tregs with disease-suppressive activity that was abolished by anti-CTLA4 mAb treatment. These findings were paralleled by macroscopic and microscopic clearance of the diseased murine skin. Anti-IL-17 mAb treatment also diminished the psoriatic phenotype of the mice. This indicated that both induced Tregs involving CTLA4 signaling and inhibition of the IL-23/Th17 axis are central for the therapeutic action of PUVA.

CiteULike: 8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.: "Singh, T. P. P., Schön, M. P., Wallbrecht, K., Michaelis, K., Rinner, B., Mayer, G., Schmidbauer, U., Strohmaier, H., Wang, X.-J. J., and Wolf, P. (2010). 8-methoxypsoralen plus ultraviolet a therapy acts via inhibition of the il-23/th17 axis and induction of foxp3+ regulatory t cells involving ctla4 signaling in a psoriasis-like skin disorder. Journal of immunology (Baltimore, Md. : 1950), 184(12):7257-7267."