"Demyelination and oligodendrocyte degeneration in this model follows astrocyte pathology. Similar structural abnormalities were also seen in a subset of active lesions in multiple sclerosis. Our studies suggest that astrocyte injury may be an important early step in the cascade of lesion formation in brain inflammation."
CiteULike: Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination:
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