Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines.

In highly aggressively proliferating immortalized (HAPI) cells, a rat microglial cell line, METH reduced cell viability in a concentration- and time-dependent manner and initiated the expression of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha. METH also induced the production of both ROS and RNS in microglial cells. Pretreatment with melatonin, a major secretory product of the pineal gland, abolished METH-induced toxicity, suppressed ROS and RNS formation and also had an inhibitory effect on cytotoxic factor gene expression

CiteULike: Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines.: "Tocharus, J., Khonthun, C., Chongthammakun, S., and Govitrapong, P. (2010). Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines. Journal of pineal research, 48(4):347-352."