NO availability, critical for vascular tone and normal function, is reduced in insulin resistance, including diabetes. Diabetes has been associated with exposures and bioaccumulation of persistant organic pollutants.
CiteULike: Insulin Reduces Plasma Arginase Activity in Type 2 Diabetic Patients: "Kashyap, S. R., Lara, A., Zhang, R., Park, Y. M., and DeFronzo, R. A. (2008). Insulin reduces plasma arginase activity in type 2 diabetic patients. Diabetes Care, 31(1):134-139."
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